Dynamic combinatorial chemistry in drug discovery, bioorganic chemistry, and materials science by Benjamin L. Miller

Cover of: Dynamic combinatorial chemistry | Benjamin L. Miller

Published by Wiley in Hoboken, N.J .

Written in English

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Subjects:

  • Combinatorial chemistry

Edition Notes

Includes index.

Book details

StatementBenjamin L. Miller.
Classifications
LC ClassificationsQD262 .M64 2009
The Physical Object
Paginationp. cm.
ID Numbers
Open LibraryOL23230000M
ISBN 109780470096031
LC Control Number2009019344

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This long-awaited first book on this exciting new field in organic and supramolecular chemistry explains the fundamentals as well as possible applications of Dynamic Combinatorial Chemistry (DCC).

Authored by the 'Who's Who' of DCC it spans Dynamic combinatorial chemistry book whole range of topics: catalysts, sensors, polymers, ligands, receptors, concluding with a look at future developments and : $ This long-awaited first book on this exciting new field in organic and supramolecular chemistry explains the fundamentals as well as possible applications of DCC.

Authored by the Whos Who of DCC it spans the whole range of topics: catalysts, sensors, polymers, ligands, receptors, concluding with a look at future developments and perspectives.

Dynamic Combinatorial Chemistry: In Drug Discovery, Bioorganic Chemistry, and Materials Science: Medicine & Health Science Books @   This long-awaited first book on this exciting new field in organic and supramolecular chemistry explains the fundamentals as well as possible applications of DCC.

Authored by the "Who's Who" of DCC it spans the whole range of topics: catalysts, sensors, polymers, ligands, receptors, concluding with a look at future developments and perspectives. About this book. In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular recognition, lead compound identification, catalyst design, nanotechnology, polymer science, and others.

Dynamic combinatorial chemistry (DCC) – combinatorial Dynamic combinatorial chemistry book under ther- modynamic control – is a tool for the effi cient synthesis of libraries of complex structures whose individual properties may be explored through the library ’ s response to the stabilizing infl uences of external stimuli.

Thiosemicarbazone Dynamic Combinatorial Chemistry: Equilibrator-Induced Dynamic State, Formation of Complex Libraries, and a Supramolecular On/Off Switch. The Journal of Organic Chemistry82 (16), DOI: /7bCited by: Dynamic combinatorial chemistry revisited: why it’s so difficult Last year we discussed the application of dynamic combinatorial chemistry (DCC) to fragment linking.

The idea is that a protein will shift the equilibrium of a reversible reaction, selecting the tightest : Dan Erlanson. 動的コンビナトリアル化学(Dynamic Combinatorial Chemistry: DCC)は、分子認識・超分子化学の考え方に基づいた、新たなホスト-ゲスト相互作用の探索手法である。年にノーベル賞学者のジャン=マリー・レーンによって提唱された概念 [1] 。.

安定に単離された分子を構成要素とする従来の. By merging features of both areas, dynamic combinatorial chemistry (DCC) offers access to a wide range of substances assembled from relatively small libraries, without the need to synthesize each Cited by: Effective techniques for applying Dynamic Combinatorial Chemistry In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of Price: $ DYNAMIC COMBINATORIAL CHEMISTRY: AN INTRODUCTION 3 of calixarenes from para - alkylphenols and formaldehyde (Fig.

), and observed that product distributions were altered based on a large number of factors [ 10 ]. Of particular interest to DCC, the authors described. In summary, dynamic combinatorial chemistry is a promising technique in cases where recognition events can be recruited to select, stabilize and thus amplify the desired library members.

No previous understanding of the interactions involved in the recognition process is required. A receptor needs no guidance to select its best ligand and vice by: If the address matches an existing account you will receive an email with instructions to reset your password.

This long-awaited first book on this exciting new field in organic and supramolecular chemistry explains the fundamentals as well as possible applications of DCC. Authored by the "Who's Who" of DCC it spans the whole range of topics: catalysts, sensors, polymers, ligands, receptors, concluding with a look at future developments and perspectives.

Dynamic combinatorial chemistry is an alternative method of producing compounds other than the classic mix and split method. Which of the following statements is true about dynamic combinatorial chemistry. a) the target should be absent from the reaction flask b) there is no scope for amplification.

Dynamic combinatorial chemistry with diselenides and disulfides in water - Chemical Communications (RSC Publishing) Diselenide exchange is introduced as a reversible reaction in dynamic combinatorial chemistry in water.

Dynamic Combinatorial Chemistry The number of irreversible reactions used in the formation of synthetically useful covalent bonds largely outweighs that of reversible ones. Yet, the last period has witnessed - Selection from Advances in Physical Organic Chemistry [Book] Skip to main content.

Dynamic combinatorial chemistry. [Joost N H Reek; Sijbren Otto;] -- This long-awaited first book on this exciting new field in organic and supramolecular chemistry explains the fundamentals as well as possible applications of DCC.

Title: Dynamic Combinatorial Chemistry VOLUME: 4 ISSUE: 1 Author(s):Ivan Huc and Regis Nguyen Affiliation:IECB-Polytechnique, 16,Av. Pey Berland, Pessac Cedex, France Keywords:Dynamic Combinatorial, potential diversity, dynamic generation, Si NMR, polycyclic oligomers, rational equilibiria, intramollecular forces, oligoamide 2 Abstract: Dynamic combinatorial chemistry is based on the Cited by: It makes virtual combinatorial libraries of substances accessible through a dynamic approach to combinatorial chemistry.

The thermodynamically‐driven evolution of the system leads to the actual expression of the constituent(s) that present(s) the best binding to/molecular recognition with the target site (see diagram). Dynamic combinatorial chemistry is a supramolecular approach that uses a self-assembly process to generate libraries of chemical compounds.

Cited by: Constitutional Dynamic Chemistry: Bridge from Supramolecular Chemistry to Adaptive Chemistry, by Jean-Marie Lehn Multistate and Phase Change Selection in Constitutional Multivalent Systems, by Mihail Barboiu Dynamic Systemic Resolution, by Morakot Sakulsombat, Yan Zhang and Olof Ramström Dynamic Combinatorial Self-Replicating Systems, by Emilie Moulin and Nicolas Giuseppone DCC in.

Print book: EnglishView all editions and formats Summary: This book presents an overview of dynamic combinatorial chemistry (DCC) and fragment-based library methods and how chemists apply them to the problems of lead generation for drug discovery and molecular recognition in bioorganic chemistry and materials science.

This book presents an overview of dynamic combinatorial chemistry (DCC) and fragment-based library methods and how chemists apply them to the problems of lead generation for drug discovery and molecular recognition in bioorganic chemistry and materials : Hardcover.

Effective techniques for applying Dynamic Combinatorial Chemistry. In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular recognition, lead compound identification, catalyst design, nanotechnology, polymer science.

Dynamic combinatorial chemistry () sounds incredibly idea is that libraries spontaneously form and reform. Add a protein and Le Châtelier's principle favors the formation of the best binders. In other words, not only does cream rise to the top, more cream is actually : Dan Erlanson.

Dynamic covalent chemistry (DCvC) is a synthetic strategy employed by chemists to make complex supramolecular assemblies from discrete molecular building blocks. DCvC has allowed access to complex assemblies such as covalent organic frameworks, molecular knots, polymers, and novel macrocycles.

Not to be confused with dynamic combinatorial chemistry, DCvC concerns only. Effective techniques for applying Dynamic Combinatorial Chemistry In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular recognition, lead compound identification, catalyst design, nanotechnology, polymer.

The novel azobenzene-based monomer 1 was prepared, equipped with the necessary functionality to undergo simultaneous dynamic exchange processes: hydrazone exchange and photoisomerization.

Acid-promoted hydrolysis of the azobenzene building block produced a dynamic combinatorial library of cyclic oligomers, while multibuilding block libraries were also generated upon addition of proline-based Cited by: Request PDF | Polymers Formed by Dynamic Combinatorial Chemistry | IntroductionDynamics in PolymersBiasing Composition by Molecular RecognitionConclusions and OutlookReferences |.

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Patrick: An Introduction to Medicinal Chemistry 6e Chapter Instructions. Dynamic combinatorial chemistry is an alternative method of producing compounds other than the classic mix and split method.

Which of the following statements is true about dynamic combinatorial chemistry. About the book. Find out more, read a sample chapter. Integration of dynamic combinatorial chemistry and scale effect was designed to realize the efficient synthesis of bioactive compounds.

Synthetic efficiency in the esterification reaction and combinatorial synthesis was significantly improved in smaller characteristic : Wei He, Yuan Gao, Guiqin Zhu, Hao Wu, Zheng Fang, Kai Guo.

[15][16][17] When dynamic covalent chemistry is applied to the preparation of dynamic combinatorial libraries, 18,19 library members are interconnected by reversible reactions and can be. Combinatorial Chemistry 1.

Library synthesis a) in solution, parallel synthesis b) on solid support c) split and combine, one bead one compound 2.

Deconvolution and Tagging 3. Dynamic combinatorial Chemistry and virtual libraries Outline V. Diversity oriented synthesis (DOS) Principle and examples Molecular complexity VI. Complexity. Reversibility of dithioacetal bond formation is reported under acidic mild conditions.

Its utility for dynamic combinatorial chemistry was explored by combining it with orthogonal disulfide exchange. In such a setup, thiols are positioned at the intersection of both chemistries, constituting a connecting node between temporally separated networks. Dynamic Combinatorial Chemistry Schematic of a Dynamic Combinatorial Chemistry (DCC) experiment.

Identifying high-affinity small molecule binders for medically relevant drug targets typically involves the iterative synthesis of large numbers of compounds. Dynamic Combinatorial Chemistry with Novel Dithiol Building Blocks: Towards New Structurally Diverse and Adaptive Screening Collections.

Searchable dynamic peptide libraries, which are based on the sequence exchange of unprotected peptides under user-defined conditions, can be used to discover self-assembled peptide by:. Virtual combinatorial chemistry is a conceptually different approach that rests on supramolecular chemistry.

It relies on a reversible connection process for the spontaneous and continuous generation of all possible combinations of a set of basic components, thus making virtually available all structural and interactional features that these. Dynamic combinatorial chemistry (DCC); also known as constitutional dynamic chemistry (CDC) is a method to the generation of new molecules formed by reversible reaction of simple building blocks.Protein-directed dynamic combinatorial chemistry is an emerging technique for efficient discovery of novel chemical structures for binding to a target protein.

Typically, this method relies on a library of small molecules that react reversibly with each other to generate a combinatorial library. The components in the combinatorial library are at equilibrium with each other under thermodynamic Cited by:

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